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High-Performance DNA Variant Libraries

Single pool plasmid libraries

>95% desired variants (<5% wildtype)

up to 1012 variants per library

2 week delivery




Combinatorial Libraries

Mutate multiple nearby or distal positions simultaneously

Choose any set of amino acids or codons


Enzyme Engineering


Optimize an enzyme active site

Alter substrate specificity and selectivity


Antibody/binder Engineering

Naïve CDR randomization

Affinity-maturation




Scanning and Random Libraries

Introduce one or multiple mutations per variant

Choose any set of amino acids or codons

Superior to error-prone PCR - access to all amino acids (100% vs. 32%)


Enzyme Engineering

Discover difficult-to-predict mutations that enhance stability and expression

Enhance stability and expression


Antibody/binder Engineering

Discover beneficial framework mutations

Optimize CDR loops

Fc engineering

Epitope mapping





Molecular biology

Map key promoter binding sites

Transcription factor engineering

Fluorescent protein engineering

Virus and protein evolution

Protein fitness landscapes

Alanine scanning


Viral gene delivery

Optimize tissue tropism