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Shifting Fitness and Epistatic Landscapes Reflect Trade-offs along an Evolutionary Pathway

Steinberg B, Ostermeier M
Journal of Molecular Biology (2016)

Environmental changes bridge evolutionary valleys

Steinberg B, Ostermeier M
Science Advances (2016)

Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions

Wolf C, Siegel JB, Tinberg C, Camarca A, Gianfrani C, Paski S, Guan R, Montelione G, Baker D, Pultz IS
Journal of the American Chemical Society (2015)

Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing

Kowalsky CA, Faber MS, Nath A, Dann HE, Kelly VW, Liu L, Shanker P, Wagner EK, Maynard JA, Chan C, Whitehead TA
Journal of Biological Chemistry (2015)

Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli

Klesmith JR, Bacik JP, Michalczyk R, Whitehead TA
ACS Synthetic Biology (2015)

High-resolution sequence-function mapping of full-length proteins

Kowalsky CA, Klesmith JR, Stapleton JA, Kelly V, Reichkitzer N, Whitehead TA
PLoS ONE (2015)

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

Guntas G, Halletta RA, Zimmermana SP, Williamsa T, Yumerefendia H, Bear JE, Kuhlman B
PNAS USA (2015)

An Experimentally Informed Evolutionary Model Improves Phylogenetic Fit to Divergent Lactamase Homologs

Bloom JD
Molecular Biology and Evolution (2014)

A comprehensive, high-resolution map of a gene's fitness landscape

Firnberg E, Labonte JW, Gray JJ, Ostermeier MA
Molecular Biology and Evolution (2014)

The genetic code constrains yet facilitates Darwinian evolution

Firnberg E, Ostermeier MA
Nucleic Acids Research (2013)

PFunkel: efficient, expansive, user-defined mutagenesis

Firnberg E, Ostermeier MA
PLoS ONE (2012)