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Select Publications
mRhubarb: Engineering of monomeric, red-shifted, and brighter variants of iRFP using structure-guided multi-site mutagenesis
Rogers OC, Johnson DM, Firnberg E
Scientific Reports (2019)
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Rimbault C, Maruthi K, Breillat C, Genuer C, Crespillo S, Puente-Muñoz V, Chamma I, Gauthereau I, Antoine S, Thibaut C, Jun Tai FW, Dartigues B, Grillo-Bosch D, Claverol S, Poujol C, Choquet D, Mackereth CD & Sainlos M
Nature Communications (2019)
Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction
Thisted T, Biesova Z, Walmacq C, Stone E, Rodnick-Smith M, Ahmed SS, Horrigan S, Engelen BV, Reed C, Kalnik MW
BMC Biotechnology (2019)
Shifting Fitness and Epistatic Landscapes Reflect Trade-offs along an Evolutionary Pathway
Steinberg B, Ostermeier M
Journal of Molecular Biology (2016)
Environmental changes bridge evolutionary valleys
Steinberg B, Ostermeier M
Science Advances (2016)
Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions
Wolf C, Siegel JB, Tinberg C, Camarca A, Gianfrani C, Paski S, Guan R, Montelione G, Baker D, Pultz IS
Journal of the American Chemical Society (2015)
Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing
Kowalsky CA, Faber MS, Nath A, Dann HE, Kelly VW, Liu L, Shanker P, Wagner EK, Maynard JA, Chan C, Whitehead TA
Journal of Biological Chemistry (2015)
Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli
Klesmith JR, Bacik JP, Michalczyk R, Whitehead TA
ACS Synthetic Biology (2015)
High-resolution sequence-function mapping of full-length proteins
Kowalsky CA, Klesmith JR, Stapleton JA, Kelly V, Reichkitzer N, Whitehead TA
PLoS ONE (2015)
Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins
Guntas G, Halletta RA, Zimmermana SP, Williamsa T, Yumerefendia H, Bear JE, Kuhlman B
PNAS USA (2015)
An Experimentally Informed Evolutionary Model Improves Phylogenetic Fit to Divergent Lactamase Homologs
Bloom JD
Molecular Biology and Evolution (2014)
A comprehensive, high-resolution map of a gene's fitness landscape
Firnberg E, Labonte JW, Gray JJ, Ostermeier MA
Molecular Biology and Evolution (2014)
The genetic code constrains yet facilitates Darwinian evolution
Firnberg E, Ostermeier MA
Nucleic Acids Research (2013)
PFunkel: efficient, expansive, user-defined mutagenesis
Firnberg E, Ostermeier MA
PLoS ONE (2012)